期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 88, 页码 11653-11656出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc05294b
关键词
-
资金
- European Research Council [ERC-337776]
- Spanish Government [CTQ2016-78779-R, PID2019107380GB-I00]
The study demonstrates that pyridine-boryl complexes can be utilized as super-electron donors to facilitate the coupling of thiols and aromatic halides via a S(RN)1 mechanism. The reaction shows high efficiency with a wide substrate scope, tolerating heterocycles and various functional groups, and has potential applications in drug synthesis and functionalized polythioethers.
We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a S(RN)1 mechanism. The reaction is efficient for a broad substrate scope, tolerating heterocycles including pyridines, enolizable or reducible functional groups. The method has been applied to intermediates in drug synthesis as well as interesting functionalized polythioethers through a controlled and consecutive intramolecular electron transfer process.
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