Spontaneous Conversion of Lamellar Macular Holes to Full-Thickness Macular Holes: Clinical Features and Surgical Outcomes

Purpose: To describe the clinical features and surgical outcomes of patients experiencing a spontaneous conversion of a lamellar macular hole (LMH) to a full-thickness macular hole (FTMH). Design: Retrospective, multicenter, observational case series. Participants: Patients with LMH who experienced a spontaneous conversion to FTMH and underwent FTMH surgery. Methods: Clinical charts and OCT features of 20 eyes of 20 patients were reviewed. Main Outcome Measures: OCT features and surgical outcomes of FTMH derived from LMH. Results: The mean baseline visual acuity (VA) was 0.21 +/- 0.19 logarithm of the minimum angle of resolution (logMAR) (20/32 Snellen equivalent [SE]). Epiretinal proliferation was noted in 18 eyes (90%), and 14 eyes (75%) had an epiretinal membrane. At the diagnosis of FTMH, the mean VA decreased to 0.61 +/- 0.50 logMAR (20/81 SE) (P = 0.001). The mean FTMH diameter was 224.4 +/- 194.8 mu m, with 15 (75%) small (<= 250 mu m), 2 (10%) medium (>250-<= 400 mu m), and 3 (15%) large (>400 mu m) FTMHs. Eighteen (90%) FTMHs were sealed after 1 surgery, and 2 (10%) required an additional procedure. At the last follow-up, the mean VA was increased to 0.29 +/- 0.23 logMAR (20/38 SE) (P = 0.003), but did not significantly differ from the baseline VA (P = 0.071). Conclusions: Patients with LMH may develop an FTMH with no evidence of vitreomacular traction. A tangential traction from an epiretinal membrane may contribute to its genesis, but a progressive loss of retinal tissue and an inherent weakness of the foveal architecture in LMH eyes could be sufficient. Most FTMHs derived from LMH had a small diameter, showed epiretinal proliferation, showed limited retinal hydration, and were associated with relatively poor surgical outcomes compared with idiopathic FTMH. (C) 2021 by the American Academy of Ophthalmology

Automated summary

This study investigates the clinical features and surgical outcomes of patients with spontaneous conversion of lamellar macular hole (LMH) to full-thickness macular hole (FTMH). Most FTMHs derived from LMH had a small diameter, showed epiretinal proliferation, and were associated with relatively poor surgical outcomes.