期刊
OPHTHALMOLOGY RETINA
卷 5, 期 10, 页码 1043-1051出版社
ELSEVIER INC
DOI: 10.1016/j.oret.2020.12.012
关键词
Macular degeneration; Retina; Retinal degeneration; Retinal dystrophy
资金
- Foundation Fighting Blindness, Columbia, Maryland
- Pan-American Association of Ophthalmology, Arlington, Texas
- National Institutes of Health, Bethesda, Maryland [5R01EY021237-04, 5R01EY027335]
This study found that reticular pseudodrusen are commonly seen in patients with Late-Onset Retinal Degeneration (L-ORD) at a younger age compared to individuals with age-related macular degeneration (AMD). RPD in L-ORD show quick formation and collapse, changes in morphologic features over time, relative foveal sparing, and are also located in the peripheral retina.
Purpose: To characterize the association of reticular pseudodrusen (RPD) with late-onset retinal degeneration (L-ORD) using multimodal imaging. Design: Prospective, 2-center, longitudinal case series. Participants: Twenty-nine patients with L-ORD. Methods: All patients were evaluated within a 3-year interval with near-infrared reflectance, fundus auto-fluorescence, and spectral-domain OCT. In addition, a subset of patients also underwent indocyanine green angiography, fundus fluorescein angiography, mesopic microperimetry, and multifocal electroretinography. Main Outcome Measures: Prevalence, topographic distribution, and temporal phenotypic changes of RPD in L-ORD. Results: A total of 29 patients with molecularly confirmed L-ORD were included in this prospective study. Reticular pseudodrusen was detected in 18 patients (62%) at baseline, 10 of whom were men. The prevalence of RPD varied with age. The mean age of RPD patients was 57.3 +/- 7.2 years. Reticular pseudodrusen was not seen in patients younger than the fifth decade of life (n = 3 patients) or in the eighth decade of life (n = 5 patients). Reticular pseudodrusen were found commonly in the macula with relative sparing of the fovea and also were identified in the peripheral retina. The morphologic features of RPD changed with follow-up. Two patients (3 eyes) demonstrated RPD regression. Conclusions: Reticular pseudodrusen is found frequently in patients with L-ORD and at a younger age than in individuals with age-related macular degeneration (AMD). Reticular pseudodrusen exhibits quick formation and collapse, change in type and morphologic features with time, and relative foveal sparing and also has a peripheral retinal location in L-ORD. (C) 2020 by the American Academy of Ophthalmology
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