An efficient solvent-free synthesis of pyrido[2,3-d]pyrimidine derivatives utilizing lactic acid as green and eco-friendly catalyst

An efficient, solvent-free and one-pot procedure for the synthesis of pyrido[2,3-d]pyrimidine derivatives by condensation of aromatic aldehydes, malononitrile and 6-amino-1,3-dimethyl uracil at 90 degrees C catalyzed by lactic acid as an inexpensive, biological and eco-friendly compound is described. The remarkable benefits of this procedure are green and environmentally friendly reaction conditions, high yields, short reaction time, simple methodology and easy workup.

Automated summary

The synthesis of pyrido[2,3-d]pyrimidine derivatives using lactic acid as a catalyst at 90 degrees C in a solvent-free and one-pot procedure is described. The benefits include green and environmentally friendly reaction conditions, high yields, short reaction time, simple methodology, and easy workup.