期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 10, 页码 7524-7531出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.1c00767
关键词
nanopillar surfaces; durability; antimicrobial materials; zinc oxide; reactive oxygen species
资金
- Institute of Bioengineering and Bioimaging (Biomedical Research Council, Agency for Science, Technology and Research)
- NanoBio Lab (Biomedical Research Council, Agency for Science, Technology and Research)
- A*STAR Infections Diseases Labs (Biomedical Research Council, Agency for Science, Technology and Research)
- Institute of Materials Research and Engineering (Science and Engineering Research Council, Agency for Science, Technology and Research)
- National Research Foundation (NRF), the Prime Minister's Office, Singapore, under its NRF Competitive Research Program [NRF-CRP19-2017-02]
The ZnO nanopillar surface shows promise in terms of large-scale synthesis, material durability, and biocompatibility. It maintains stable antimicrobial activity even under highly accelerated lifetime tests, making it effective against clinically isolated pathogens. These findings highlight the potential broad applicability of ZnO nanopillar surfaces in healthcare and consumer industries.
Much attention has been devoted to the synthesis and antimicrobial studies of nanopatterned surfaces. However, factors contributing to their potential and eventual application, such as large-scale synthesis, material durability, and biocompatibility, are often neglected in such studies. In this paper, the ZnO nanopillar surface is found to be amenable to synthesis in large forms and stable upon exposure to highly accelerated lifetime tests (HALT) without any detrimental effect on its antimicrobial activity. Additionally, the material is effective against clinically isolated pathogens and biocompatible in vivo. These findings illustrate the broad applicability of ZnO nanopillar surfaces in the common equipment used in health-care and consumer industries.
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