Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: an efficient endocytic drug carrier

A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin and can successfully penetrate cancer cells through caveolae-dependent endocytosis, compared to the free drug.

Automated summary

A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles with tunable morphology by varying the hydrophilic chain length. These 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, exhibited sustained release of the drug, and effectively penetrated cancer cells through caveolae-dependent endocytosis.