Polymer based nanoparticles for biomedical applications by microfluidic techniques: from design to biological evaluation

The development of microfluidic technologies represents a new strategy to produce and test drug delivery systems. In particular, microfluidics can facilitate the development of new nanoparticle-based systems with controlled physicochemical properties and evaluate their efficiency and efficacy in in vitro biomimetic models of human organs (organ-on-a-chip). Microfluidics shows promising effective potential for the preclinical testing of nanoparticle-based drug delivery systems compared to the traditional in vitro cell culture. In this review, we present a detailed state-of-the-art based on the microfluidic technologies focusing on the synthesis, industrial scale-up, and biological characterization of polymeric nanoparticles for drug delivery applications.

Automated summary

The development of microfluidic technologies has shown promising potential in producing and testing drug delivery systems, particularly in the synthesis, industrial scale-up, and biological characterization of nanoparticle-based systems for drug delivery applications.