Metal-hydride hydrogen atom transfer (MHAT) reactions in natural product synthesis

The metal-hydride hydrogen atom transfer (MHAT) reaction plays an important role in the field of natural product synthesis. MHAT, as a powerful method, has been employed by chemists to construct C-C, C-H, and C-heteroatom bonds. In this review, we summarize the recent total synthesis of natural products using MHAT to functionalize olefins with first-row transition metal catalysts such as cobalt, manganese and iron.

Automated summary

The MHAT reaction is a powerful method in natural product synthesis for constructing C-C, C-H, and C-heteroatom bonds. Recent studies have shown that using first-row transition metal catalysts such as cobalt, manganese, and iron can achieve total synthesis of natural products through MHAT functionalization of olefins.