DITERPENOID ALKALOIDS FROM ACONITUM LEUCOSTOMUM AND THEIR ANTIFEEDANT ACTIVITY

Two new diterpenoid alkaloids and eight known ones were isolated from the root of Aconitum leucostomum. Their structures were elucidated on the basis of extensive spectroscopic analyses such as HR-ESI-MS, 1D NMR and 2D NMR spectra. Compounds 1, 2, 5, 6 and 8 were tested for their antifeedant activity against Spodoptera exigua Hubner, and compound 2 showed antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 1.54 mg/cm(2).

Automated summary

Two new diterpenoid alkaloids and eight known ones were isolated from the root of Aconitum leucostomum. Compound 2 showed antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 1.54 mg/cm(2).