4.7 Article

Dearomatization-rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions

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Tyrosine-Specific Modification via a Dearomatization-Rearomatization Strategy: Access to Azobenzene Functionalized Peptides

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Summary: An efficient approach to preparing azobenzene functionalized peptides through late-stage modification of tyrosine-containing peptides using a dearomatization-rearomatization strategy was reported. This method demonstrates good chemoselectivity, site selectivity, and sensitivity to various peptides, enriching the postsynthetic modification toolbox of peptides and showing great potential for applications in medicinal chemistry and chemical biology.

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