期刊
NEUROTRAUMA REPORTS
卷 -, 期 -, 页码 488-501出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neur.2021.0039
关键词
aging; biological sex; cerebrovascular reactivity; signal processing; TBI
资金
- Manitoba Public Insurance (MPI) Neuroscience/TBI Research Endowment
- Health Sciences Centre Foundation Winnipeg, the United States National Institutes of Health (NIH) through the National Institute of Neurological Disorders and Stroke (NINDS) [R03NS114335-01]
- Canadian Institutes of Health Research (CIHR) [432061]
- Canada Foundation for Innovation (CFI) [38583]
- Research Manitoba [3906]
- University of Manitoba VPRI Research Investment Fund (RIF)
- University of Manitoba Rudy Falk Clinician-Scientist Professorship
- University of Manitoba Clinician Investigator Program
- University of ManitobaDepartment of Surgery GFT Research Grant
- University of Manitoba Office of Research Services (ORS)University Research Grant Program (URGP)
- Centre on Aging at the University of Manitoba
Age and biological sex can impact cerebrovascular reactivity post-TBI, with age showing a positive linear relationship with certain cerebrovascular function measures. In this study, biological sex did not have a significant impact on cerebrovascular reactivity indices. Further research is needed to validate these findings and explore the utility of different cerebrovascular reactivity indices, with PAx and RAC potentially being better metrics for detecting impaired cerebrovascular reactivity in elderly patients.
Age and biological sex are two potential important modifiers of cerebrovascular reactivity post-traumatic brain injury (TBI) requiring close evaluation for potential subgroup responses. The goal of this study was to provide a preliminary exploratory analysis of the impact of age and biological sex on measures of cerebrovascular function in moderate/severe TBI. Forty-nine patients from the prospectively maintained TBI database at the University of Manitoba with archived high-frequency digital cerebral physiology were evaluated. Cerebrovascular reactivity indices were derived as follows: PRx (correlation between intracranial pressure [ICP] and mean arterial pressure [MAP]), PAx (correlation between pulse amplitude of ICP [AMP] and MAP), and RAC (correlation between AMP and cerebral perfusion pressure [CPP]). Time above clinically significant thresholds for each index was calculated over different periods of the acute intensive care unit stay. The association between PRx, PAx, and RAC measures with age was assessed using linear regression, and an age trichotomization scheme (<40, 40-60, >60) using Kruskal-Wallis testing. Similarly, association with biological sex was tested using Mann-Whitney U testing. Biological sex did not demonstrate an impact on any measures of cerebrovascular reactivity. Linear regression between age and PAx and RAC demonstrated a statistically significant positive linear relationship. Median PAx and RAC measures between trichotomized age categories demonstrated statistically significant increases with advancing age. The PRx failed to demonstrate any statistically significant relationship with age in this cohort, suggesting that in elderly patients with controlled ICP, PAx and RAC may be better metrics for detecting impaired cerebrovascular reactivity. Biological sex appears to not be associated with differences in cerebrovascular reactivity in this cohort. The PRx performed the worst in detecting impaired cerebrovascular reactivity in those with advanced age, where PAx and RAC appear to have excelled. Future work is required to validate these findings and explore the utility of different cerebrovascular reactivity indices.
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