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Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
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RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
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EUROPEAN JOURNAL OF IMMUNOLOGY (2013)
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EUROPEAN JOURNAL OF IMMUNOLOGY (2013)
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IMMUNITY (2013)
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INTENSIVE CARE MEDICINE (2013)
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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)
Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones
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Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
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Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury
Hai Huang et al.
JOURNAL OF IMMUNOLOGY (2013)
HMGB1 mediates splenomegaly and expansion of splenic CD11b+Ly-6Chigh inflammatory monocytes in murine sepsis survivors
S. I. Valdes-Ferrer et al.
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Distinct effects of Re- and S-forms of LPS on modulating platelet activation
J. Kappelmayer et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
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MOLECULAR CELL (2013)
Sphingosine kinase-1 mediates endotoxemia-induced hyperinflammation in aged animals
Maria Lufrano et al.
MOLECULAR MEDICINE REPORTS (2013)
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G. M. Tannahill et al.
NATURE (2013)
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
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NATURE IMMUNOLOGY (2013)
NEW FUNDAMENTALS IN HEMOSTASIS
Henri H. Versteeg et al.
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Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
Roshan J. Thapa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection
Hideyuki Yanai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
Nobuhiko Kayagaki et al.
SCIENCE (2013)
Tissue Factor De-encryption, Thrombus Formation, and Thiol-disulfide Exchange
Vivien M. Y. Chen
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2013)
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TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis
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PLOS PATHOGENS (2013)
Roles of autophagy in elimination of intracellular bacterial pathogens
Eun-Kyeong Jo et al.
FRONTIERS IN IMMUNOLOGY (2013)
Thrombosis as an intravascular effector of innate immunity
Bernd Engelmann et al.
NATURE REVIEWS IMMUNOLOGY (2013)
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Roxane Darbousset et al.
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The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling
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The origin and properties of extracellular DNA: From PAMP to DAMP
David S. Pisetsky
CLINICAL IMMUNOLOGY (2012)
Sphingosine regulates the NLRP3-inflammasome and IL-1ß release from macrophages
Nadia M. Luheshi et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
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IMMUNITY (2012)
Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
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Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury
Axelle Caudrillier et al.
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HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
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Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
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JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
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Clinical Sepsis in Neonates and Young Infants, United States, 1988-2006
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Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
被撤回的出版物: Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1) (Publication with Expression of Concern. See vol. 26, 2020) (Retracted article. See vol. 26, 2020)
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MOLECULAR MEDICINE (2012)
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
Petr Broz et al.
NATURE (2012)
Novel role of PKR in inflammasome activation and HMGB1 release
Ben Lu et al.
NATURE (2012)
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
Chong-Shan Shi et al.
NATURE IMMUNOLOGY (2012)
Drotrecogin Alfa (Activated) in Adults with Septic Shock
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NEW ENGLAND JOURNAL OF MEDICINE (2012)
Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones
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PLOS ONE (2012)
Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis
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PLOS ONE (2012)
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Tomohiko Murakami et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Calcium/Calmodulin-Dependent Protein Kinase is Involved in the Release of High Mobility Group Box 1 Via the Interferon-β Signaling Pathway
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Immune Network (2012)
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Systemic infections mimicking thrombotic thrombocytopenic purpura
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Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia A Randomized Trial
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High-Mobility Group Box 1, Oxidative Stress, and Disease
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Histones induce rapid and profound thrombocytopenia in mice
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Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
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Endogenous Histones Function as Alarmins in Sterile Inflammatory Liver Injury Through Toll-like Receptor 9 in Mice
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RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
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IMMUNITY (2011)
Early rise in circulating endothelial protein C receptor correlates with poor outcome in severe sepsis
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INTENSIVE CARE MEDICINE (2011)
P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice
Christian Furlan-Freguia et al.
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Suppression of high-mobility group box-1 and receptor for advanced glycation end-product axis by polymyxin B-immobilized fiber hemoperfusion in septic shock patients
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Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury
Jun Xu et al.
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Early-onset neonatal sepsis: rate and organism pattern between 2003 and 2008
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Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation
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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
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RIP3 mediates the embryonic lethality of caspase-8-deficient mice
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NATURE (2011)
Functional complementation between FADD and RIP1 in embryos and lymphocytes
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NATURE (2011)
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Ischemia and reperfusion-from mechanism to translation
Holger K. Eltzschig et al.
NATURE MEDICINE (2011)
The Nucleosome (Histone-DNA Complex) Is the TLR9-Specific Immunostimulatory Component of Plasmodium falciparum That Activates DCs
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PLOS ONE (2011)
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway
Sudan He et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
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SCIENCE TRANSLATIONAL MEDICINE (2011)
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SHOCK (2011)
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SHOCK (2011)
Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock
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PLOS BIOLOGY (2011)
The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
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CRITICAL CARE (2011)
Prolonged Exposure to Sphingosine 1-Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury
Barry S. Shea et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)
The Sterile Inflammatory Response
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ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)
HMGB1 A novel Beclin 1-binding protein active in autophagy
Rui Kang et al.
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CRITICAL CARE MEDICINE (2010)
Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function
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Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor
Susannah K. Leaver et al.
INTENSIVE CARE MEDICINE (2010)
High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity
John Evankovich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Endogenous HMGB1 regulates autophagy
Daolin Tang et al.
JOURNAL OF CELL BIOLOGY (2010)
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
Mohamed Lamkanfi et al.
JOURNAL OF IMMUNOLOGY (2010)
Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies
J. -S. Bae et al.
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S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability
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MOLECULAR CELL (2010)
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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NATURE CELL BIOLOGY (2010)
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Rongbin Zhou et al.
NATURE IMMUNOLOGY (2010)
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases
Steffen Massberg et al.
NATURE MEDICINE (2010)
Extracellular DNA traps promote thrombosis
Tobias A. Fuchs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
Amir S. Yazdi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
THE PHOSPHOINOSITIDE-3 KINASE SURVIVAL SIGNALING MECHANISM IN SEPSIS
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SHOCK (2010)
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SHOCK (2010)
Cellular sources of tissue factor in endotoxemia and sepsis
Rafal Pawlinski et al.
THROMBOSIS RESEARCH (2010)
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
Joshua S. Davis et al.
CRITICAL CARE (2010)
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
Jurg Tschopp et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells
Jeremy Bregeon et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
The Inflammasomes: Guardians of the Body
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ANNUAL REVIEW OF IMMUNOLOGY (2009)
Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo
Felicitas Muller et al.
CELL (2009)
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
YoungSik Cho et al.
CELL (2009)
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
Sudan He et al.
CELL (2009)
Thioredoxin in human and experimental sepsis
Stefan Hofer et al.
CRITICAL CARE MEDICINE (2009)
Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)
Fabian Jaimes et al.
CRITICAL CARE MEDICINE (2009)
Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial
Didier Payen et al.
CRITICAL CARE MEDICINE (2009)
Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia
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CRITICAL CARE MEDICINE (2009)
Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways
Mario Menschikowski et al.
EXPERIMENTAL CELL RESEARCH (2009)
Mitochondria and reactive oxygen species
Alicia J. Kowaltowski et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis
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GASTROENTEROLOGY (2009)
Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock The EUPHAS Randomized Controlled Trial
Dinna N. Cruz et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)
Angiopoietin-1 Induces Kruppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2
Keisuke Sako et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
VE-PTP controls blood vessel development by balancing Tie-2 activity
Mark Winderlich et al.
JOURNAL OF CELL BIOLOGY (2009)
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
Peter Geserick et al.
JOURNAL OF CELL BIOLOGY (2009)
Concentration Dependent Dual Effect of Thrombin in Endothelial Cells Via Par-1 and Pi3 Kinase
Jong-Sup Bae et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Franz G. Bauernfeind et al.
JOURNAL OF IMMUNOLOGY (2009)
Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway
Guoying Zhang et al.
JOURNAL OF IMMUNOLOGY (2009)
Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-β Signaling Pathway
Ju-Hyun Kim et al.
JOURNAL OF IMMUNOLOGY (2009)
COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury
Duk Hoon Kim et al.
KIDNEY INTERNATIONAL (2009)
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Joseph U. Becker et al.
LANCET INFECTIOUS DISEASES (2009)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Veit Hornung et al.
NATURE (2009)
Extracellular histones are major mediators of death in sepsis
Jun Xu et al.
NATURE MEDICINE (2009)
Thrombomodulin Mutations in Atypical Hemolytic-Uremic Syndrome
Mieke Delvaeye et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis
Philipp Kuempers et al.
CRITICAL CARE (2009)
Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response
Chung-Sheng Shi et al.
BLOOD (2008)
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Peggy P. Hsu et al.
CELL (2008)
Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock
Katri Saukkonen et al.
CLINICAL CHEMISTRY (2008)
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
Hirotaka Kazama et al.
IMMUNITY (2008)
HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis
Sari Karlsson et al.
INTENSIVE CARE MEDICINE (2008)
C5a and TNF-α up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome
Konstantinos Kambas et al.
JOURNAL OF IMMUNOLOGY (2008)
Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages
Xianghong Zhang et al.
JOURNAL OF IMMUNOLOGY (2008)
Continuous hemodiafiltration with PMMA hemofilter in the treatment of patients with septic shock
Taka-aki Nakada et al.
MOLECULAR MEDICINE (2008)
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Hiroki Ishikawa et al.
NATURE (2008)
Identification of RIP1 kinase as a specific cellular target of necrostatins
Alexei Degterev et al.
NATURE CHEMICAL BIOLOGY (2008)
Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
NEW ENGLAND JOURNAL OF MEDICINE (2008)
ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way
Alessandra Piccini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
Catherine Dostert et al.
SCIENCE (2008)
Protease activated receptor I (PAR-I) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand
Jong-Sup Bae et al.
THROMBOSIS AND HAEMOSTASIS (2008)
Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNF alpha involvement
S. Rafail et al.
THROMBOSIS RESEARCH (2008)
Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer
Elena M. Egorina et al.
BLOOD (2008)
Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells
Raymond C. B. Wong et al.
STEM CELLS AND DEVELOPMENT (2007)
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a banier-protective response in endothelial cells
Jong-Sup Bae et al.
BLOOD (2007)
VEGF induces Tie2 shedding via a phosphoinositide 3-Kinase/Akt-Dependent pathway to modulate Tie2 signaling
Clarence M. Findley et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
HMGB1 release induced by liver ischemia involves Toll-like receptor 4-dependent reactive oxygen species production and calcium-mediated signaling
Allan Tsung et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
A comparative study of the protein c pathway in septic and nonseptic patients with organ failure
Delphine Borgel et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Systemic inflammation and remote organ injury following trauma require HMGB1
Ryan M. Levy et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Endotoxemia and sepsis mortality reduction by non-anticoagulant-activated protein C
Edward J. Kerschen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated)
Marcel Levi et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
V. Petrilli et al.
CELL DEATH AND DIFFERENTIATION (2007)
Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: A phase 1 randomized trial
Michael Haase et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2007)
Cutting edge:: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis
Carole Peyssonnaux et al.
JOURNAL OF IMMUNOLOGY (2007)
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: Role of HMGB1-TLR4 signaling
Jie Fan et al.
JOURNAL OF IMMUNOLOGY (2007)
The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions
Christiane D. Wrann et al.
JOURNAL OF IMMUNOLOGY (2007)
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial
Simon Nadel et al.
LANCET (2007)
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9
Peggy Parroche et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
DAMPs, PAMPs and alarmins: all we need to know about danger
Marco E. Bianchi
JOURNAL OF LEUKOCYTE BIOLOGY (2007)
Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor
Haiwang Tang et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
H. Saito et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Role of Janus kinase/signal transducer and activator of transcription pathway in regulation of expression and inflammation-promoting activity of high mobility group box protein 1 in rat peritoneal macrophages
Hui Liu et al.
SHOCK (2007)
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen R. Clark et al.
NATURE MEDICINE (2007)
Complement and coagulation: strangers or partners in crime?
Maciej M. Markiewski et al.
TRENDS IN IMMUNOLOGY (2007)
Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
Ju Ho Youn et al.
JOURNAL OF IMMUNOLOGY (2006)
VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin
Julie Gavard et al.
NATURE CELL BIOLOGY (2006)
A novel c5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways
Konstantinos Ritis et al.
JOURNAL OF IMMUNOLOGY (2006)
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages
Kinga A. Powers et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis
M. Van de Wouwer et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)
Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure
Stanislao Morgera et al.
CRITICAL CARE MEDICINE (2006)
Thrombin-cofactor interactions - Structural insights into regulatory mechanisms
Ty E. Adams et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality
Jerome Larche et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Role of HMGB1 in apoptosis-mediated sepsis lethality
Shixin Qin et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Generation of C5a in the absence of C3: a new complement activation pathway
Markus Huber-Lang et al.
NATURE MEDICINE (2006)
High-volume hemofiltration as salvage therapy in severe hyperdynamic septic shock
R Cornejo et al.
INTENSIVE CARE MEDICINE (2006)
Cryopyrin activates the inflammasome in response to toxins and ATP
S Mariathasan et al.
NATURE (2006)
Differential expression of tissue factor mRNA and protein expression in murine sepsis - The role of the granulocyte revisited
V de Waard et al.
THROMBOSIS AND HAEMOSTASIS (2006)
Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation
J Kienast et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)
Plasma concentrations and importance of high mobility group box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation
T Hatada et al.
THROMBOSIS AND HAEMOSTASIS (2005)
Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II
M David-Dufilho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Dyotyecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment
JL Vincent et al.
CRITICAL CARE MEDICINE (2005)
Platelets express functional Toll-like receptor-4
G Andonegui et al.
BLOOD (2005)
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
E Abraham et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Protease-activated receptors in hemostasis, thrombosis and vascular biology
SR Coughlin
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)
Regulation of blood coagulation by the protein C anticoagulant pathway -: Novel insights into structure-function relationships and molecular recognition
B Dahlbäck et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
KT Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Activated protein C mediates novel lung endothelial barrier enhancement - Role of sphingosine 1-phosphate receptor transactivation
JH Finigan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates Rac activation and adherens junction assembly in endothelial cells
D Mehta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
C Feistritzer et al.
BLOOD (2005)
High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal
MT Lotze et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
J Sundén-Cullberg et al.
CRITICAL CARE MEDICINE (2005)
The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
M Scharpfenecker et al.
JOURNAL OF CELL SCIENCE (2005)
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
H Yoshida et al.
NATURE IMMUNOLOGY (2005)
Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation
S Gando et al.
THROMBOSIS RESEARCH (2005)
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
C Daly et al.
GENES & DEVELOPMENT (2004)
Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial
S Opal et al.
CRITICAL CARE MEDICINE (2004)
Regulation of inflammatory responses by activated protein C: the molecular mechanism(s) and therapeutic implications
K Okajima
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2004)
Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation
JF Dhainaut et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Paladebodies
U Fiedler et al.
BLOOD (2004)
Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation
T Myles et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
T Bonaldi et al.
EMBO JOURNAL (2003)
Regulation by C5a of neutrophil activation during sepsis
NC Riedemann et al.
IMMUNITY (2003)
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
I Hrachovinová et al.
NATURE MEDICINE (2003)
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis -: A randomized controlled trial
E Abraham et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
Elevated nucleosome levels in systemic inflammation and sepsis
S Zeerleder et al.
CRITICAL CARE MEDICINE (2003)
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor
LO Mosnier et al.
BIOCHEMICAL JOURNAL (2003)
Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin
S Falati et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial
DP Schuster et al.
CRITICAL CARE MEDICINE (2003)
IFN-γ induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
B Rendon-Mitchell et al.
JOURNAL OF IMMUNOLOGY (2003)
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
MM Levy et al.
CRITICAL CARE MEDICINE (2003)
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
T Cheng et al.
NATURE MEDICINE (2003)
Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability -: The role of Rho-GTPases
SW Klarenbach et al.
CIRCULATION RESEARCH (2003)
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis
NC Riedemann et al.
FASEB JOURNAL (2003)
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
S Davis et al.
NATURE STRUCTURAL BIOLOGY (2003)
Complement-induced impairment of innate immunity during sepsis
MS Huber-Lang et al.
JOURNAL OF IMMUNOLOGY (2002)
The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor κB and mitogen-activated protein kinase pathways
EM Conway et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
P Scaffidi et al.
NATURE (2002)
Platelet function in sepsis
JL Vincent et al.
CRITICAL CARE MEDICINE (2002)
Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-κB
DE Joyce et al.
CRITICAL CARE MEDICINE (2002)
Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N
WD Campbell et al.
MICROBIOLOGY AND IMMUNOLOGY (2002)
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin αIIbβ3
ZY Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
High-dose a randomized antithrombin III in severe sepsis -: A randomized controlled trial
BL Warren et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
JGN Garcia et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Dysfunction of endothelial protein C activation in severe meningococcal sepsis.
SN Faust et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
DE Joyce et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Efficacy and safety of recombinant human activated protein C for severe sepsis.
GR Bernard et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: A randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
E Abraham et al.
CRITICAL CARE MEDICINE (2001)
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
N Holler et al.
NATURE IMMUNOLOGY (2000)
Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: A prospective, multicenter, double-blind, randomized phase II trial
M Poeze et al.
SHOCK (2000)
The role of albumin in critical illness
JP Nicholson et al.
BRITISH JOURNAL OF ANAESTHESIA (2000)
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
U Andersson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor κB (NF-κB) and tumour necrosis factor α (TNF-α) production in the THP-1 monocytic cell line
B White et al.
BRITISH JOURNAL OF HAEMATOLOGY (2000)
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
P Fuentes-Prior et al.
NATURE (2000)
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
JM Gu et al.
BLOOD (2000)
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis
JL Vincent et al.
CRITICAL CARE MEDICINE (2000)
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