期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 9, 期 47, 页码 9720-9733出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00618e
关键词
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资金
- National Natural Science Foundation of China [81901050, 81671839, 31971271]
- Shanghai Sailing program [19YF1426300]
The study evaluated a biomimetic baicalin-incorporating graphene oxide-demineralized bone matrix hybrid scaffold for bone regeneration. It demonstrated that the scaffold enhanced beneficial cross-talk among bone cells and inflammatory cells, which could be utilized as an effective strategy for bone regeneration. Additionally, the scaffold showed potential in transforming inflammatory M1 macrophages into pro-healing M2 macrophages, promoting in vitro angiogenesis and osteogenesis.
The use of an artificial bone substitute is a potential strategy for repairing bone defects; however, the inadequate consideration of repair-immune system interactions, resulting in significant pathological changes in the microenvironment, is a major barrier to achieving effective regenerative outcomes. Here, we evaluated a biomimetic baicalin (BAI)-incorporating graphene oxide-demineralized bone matrix (GO-BAI/DBM) hybrid scaffold, which was beneficial for bone regeneration. First, by considering that bone is a kind of organic-inorganic composite, a biomimetic GO/DBM bone substitute with enhanced physiochemical and osteoinductive properties was fabricated. Furthermore, inherently therapeutic GO was also used as a drug delivery carrier to achieve the sustained and prolonged release of BAI. Notably, a series of experiments showed that the GO-BAI nanocomposites could transform inflammatory M1 macrophages into pro-healing M2 macrophages, which was beneficial for in vitro angiogenesis and osteogenesis. By using a rat subcutaneous model, it was revealed that the GO-BAI nanocomposites proactively ameliorated the inflammatory response, which was coupled with decreased fibrous encapsulation. Notably, obvious in situ calvarial bone regeneration was achieved using the GO-BAI/DBM hybrid scaffold. These findings demonstrated that the bifunctional GO-BAI/DBM scaffold, by enhancing beneficial cross-talk among bone cells and inflammatory cells, might be utilized as an effective strategy for bone regeneration.
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