Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste

Human susceptibility to NaCl varies depending on temperature and pH, the molecular mechanisms of which remain unclear. The voltage-dependent chloride channel, transmembrane channel-like 4 (TMC4), is activated at approximately 40 degrees C and is suppressed at pH 5.5. As these are similar in character to human sensory evaluations, human TMC4 may be involved in human salt taste reception.

Automated summary

Human susceptibility to NaCl is influenced by temperature and pH, with TMC4 playing a potential role in human salt taste reception due to its activation at 40 degrees C and suppression at pH 5.5, which are similar to human sensory evaluations.