4.6 Review

Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 47, 页码 10245-10258

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob01431e

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资金

  1. Science Foundation for Distinguished Young Scholars for Guangdong Province [2020B1515020026]
  2. Science and Technology Program of Guangzhou [202103000089]
  3. Innovation team Project of Universities in Guangdong Province [2020KCXTD009]
  4. Scientific Research Projects for Key Disciplines of Guangdong Province [2019-GDXK-0009]
  5. Key Projects of Social Welfare and Basic Research of Zhongshan City [2020B2007]
  6. Innovation and Strong School Project of Guangdong Pharmaceutical University [2018KQNCX131]
  7. Guangdong Cosmetics Engineering & Technology Research Center
  8. Provincial Experimental Teaching Demonstration Center of Chemistry & Chemical Engineering
  9. Special funds of key disciplines construction from Guangdong and Zhongshan cooperating

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This review systematically examines the current and latest synthetic strategies using radical species or radical intermediates for synthesizing indolizines and their derivatives. The review is classified into two parts based on the type of building blocks used for indolizine ring construction and the type of radical trigger for indolizine derivative construction. We anticipate that this review will provide a deep understanding of this topic and help researchers develop novel approaches for the synthesis of indolizine and its derivatives.
Indolizine is a nitrogen-containing heterocycle that has a variety of potential biological activities, and some indolizine derivatives with excellent fluorescence properties can even be used as organic fluorescent molecules for biological and material applications. Thus, many approaches for their synthesis have been developed. Among them, radical-induced synthetic approaches are receiving increasing attention owing to their unique advantages, such as efficient heterocycle construction, efficient C-C or C-X bond construction, and high atom- and step-economy. This review systematically examines the current and latest synthetic strategies using radical species or radical intermediates for synthesizing indolizines and their derivatives. This review is classified into two parts based on the type of building blocks used for indolizine ring construction and the type of radical trigger for indolizine derivative construction. We anticipate that this review will provide a deep understanding of this topic, and ultimately help researchers to develop novel approaches for the synthesis of indolizine and its derivatives.

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