期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 49, 期 7, 页码 1577-1622出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X21500749
关键词
Schisandra Sphenanthera; chemical constituents; pharmacological; development utilization; clinical application; review
资金
- Key R&D Program of Shaanxi Province [2019ZDLSF04-03-02]
- Subject Innovation Team of Shaanxi University of Chinese Medicine [2019-YL12]
- Natural Science Basic Research Project of Department of Science and Technology of Shaanxi Province [2021JQ744]
- National Natural Science Foundation of China [82174111]
Schisandra sphenanthera is a medicinal herb with a wide range of bioactivities, including antitumor, anti-oxidant, anti-inflammatory, osteoblastic, immune regulation, neuroprotective, kidney protection, hepatoprotective, and antiviral activities. There is still a need for further studies on resource availability, quality control measures, in-depth in vivo pharmacological study, and clinical application.
Schisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly obtained from the fruits and stems of S. sphenanthera. Pharmocological studies have shown that the extracts and monomeric compounds of S. sphenanthera possessed wide-range bioactivities, such as antitumor, anti-oxidant, anti-inflammatory, osteoblastic, immune regulation, neuroprotective, kidney protection, hepatoprotective, and antiviral activities. However, resource availability, quality control measures, in-depth in vivo pharmacological study, and clinical application are still insufficient and deserve further studies. This review systematically summarized literatures on the botany, phytochemistry, pharmacology, development utilization, and clinical application of S. sphenanthera, in hopes of provide a useful reference for researchers for further studies of this plant.
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