期刊
FOOD & FUNCTION
卷 12, 期 24, 页码 12550-12564出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo02655k
关键词
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资金
- National Natural Science Foundation of China [81630104, 82074300, 81973748]
- Key-Area Research and Development Program of Guangdong Province [2020B1111100001]
- Natural Science Foundation of Guangdong Province [2021A1515010869]
- Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine [202102010014]
- K. C. Wong Education
- Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University [201911]
Oral administration of CF can alleviate depression-like behaviors induced by CUMS, improve colonic inflammation, lower levels of inflammatory cytokines, and restructure the gut microbiome. Therefore, CF administration is a promising nutritional strategy to treat CUMS-induced depression by regulating microbiota and microbial metabolism.
The gut microbiome is known to be involved in depression development. Thus, phytochemicals changing gut microbiota may alleviate depression-like behaviors. Coniferyl ferulate (CF) is a long studied natural product and known to alleviate psychiatric disorders. However, its mechanism of action remains unclear. In this experimental study, oral administration of 50 mg kg(-1) CF once daily attenuated weight loss and depression-like and anxiety-like behaviors induced by chronic unpredicted mild stress (CUMS) in mice. Four weeks of CF administration significantly ameliorated colonic inflammation, lowered the levels of IL-6, IL-1 beta, and TNF-alpha, and restructured the gut microbiome, and microbial metabolism. Intestinal microbiota can impact the development and function of the brain via the microbiota-gut-brain axis. Therefore, oral administration of CF is a promising nutritional strategy to treat CUMS-induced depression via the regulation of microbiota and microbial metabolism.
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