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L. S. Kristensen et al.
ONCOGENE (2018)
Lung cancer epigenetics: From knowledge to applications
Michael Duruisseaux et al.
SEMINARS IN CANCER BIOLOGY (2018)
TDP-43 regulates cancer-associated microRNAs
Xiaowei Chen et al.
PROTEIN & CELL (2018)
Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer
Shuangyan Tan et al.
CELL RESEARCH (2018)
Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors
Jingci Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway
Yu Huang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2018)
Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma
Jian Yu et al.
JOURNAL OF HEPATOLOGY (2018)
PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy
Nahal Haddadi et al.
MOLECULAR CANCER (2018)
Current state of immunotherapy for glioblastoma
Michael Lim et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
AGC kinases, mechanisms of regulation and innovative drug development
Alejandro E. Leroux et al.
SEMINARS IN CANCER BIOLOGY (2018)
PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux
Jake S. O'Donnell et al.
SEMINARS IN CANCER BIOLOGY (2018)
Precision Prevention and Early Detection of Cancer: Fundamental Principles
Timothy R. Rebbeck et al.
CANCER DISCOVERY (2018)
Fibroblast growth factor receptor 1 and 3 expression is associated with regulatory PI3K/AKT kinase activity, as well as invasion and prognosis, in human laryngeal cancer
Katarzyna Starska et al.
CELLULAR ONCOLOGY (2018)
Circular RNA In Invasive and Recurrent Clinical Nonfunctioning Pituitary Adenomas: Expression Profiles and Bioinformatic Analysis
Jianpeng Wang et al.
WORLD NEUROSURGERY (2018)
Circular DNA tumor viruses make circular RNAs
Tuna Toptan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
A blueprint for the primary prevention of cancer: Targeting established, modifiable risk factors
Susan M. Gapstur et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2018)
EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis
Renjie Wang et al.
MOLECULAR CANCER (2018)
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis
Fei Xie et al.
MOLECULAR CANCER (2018)
Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma
Guy Ledergor et al.
NATURE MEDICINE (2018)
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy
Paolo M. Comoglio et al.
NATURE REVIEWS CANCER (2018)
Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus
Limin Liu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)
Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma
Nur P. Damayanti et al.
CLINICAL CANCER RESEARCH (2018)
Too many targets, not enough patients: rethinking neuroblastoma clinical trials
Jamie I. Fletcher et al.
NATURE REVIEWS CANCER (2018)
Circular RNA participates in the carcinogenesis and the malignant behavior of cancer
Zhen-Jun Zhao et al.
RNA BIOLOGY (2017)
Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells
Sara Haggblad Sahlberg et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2017)
Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation and Neurodegeneration via Augmented Tuberous Sclerosis Complex-2 (TSC-2) Activation in Neuronal Cells
Premranjan Kumar et al.
MOLECULAR NEUROBIOLOGY (2017)
Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
Pablo Angulo et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis
Dawei Zhang et al.
MECHANISMS OF DEVELOPMENT (2017)
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
Ivano Legnini et al.
MOLECULAR CELL (2017)
Antibody-drug conjugates in glioblastoma therapy: the right drugs to the right cells
Hui K. Gan et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2017)
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rajesha Rupaimoole et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
Jong-Ho Lee et al.
NATURE COMMUNICATIONS (2017)
Multiple myeloma
Shaji K. Kumar et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
Microenvironment-Driven Shift of Cohesion/Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma
Celine Delloye-Bourgeois et al.
CANCER CELL (2017)
Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives
Jole Ventriglia et al.
CANCER TREATMENT REVIEWS (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning et al.
CELL (2017)
PI3K signaling in cancer: beyond AKT
Evan C. Lien et al.
CURRENT OPINION IN CELL BIOLOGY (2017)
Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer
Carl A. K. Borrebaeck
NATURE REVIEWS CANCER (2017)
HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy
Tongzheng Liu et al.
CANCER RESEARCH (2016)
The influence of subclonal resistance mutations on targeted cancer therapy
Michael W. Schmitt et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2016)
Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation
C. F. de la Cruz-Herrera et al.
ONCOGENE (2016)
Global Incidence and Mortality for Prostate Cancer: Analysis of Temporal Patterns and Trends in 36 Countries
Martin C. S. Wong et al.
EUROPEAN UROLOGY (2016)
Detecting circular RNAs: bioinformatic and experimental challenges
Linda Szabo et al.
NATURE REVIEWS GENETICS (2016)
The biogenesis and emerging roles of circular RNAs
Ling-Ling Chen
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
NON-CODING RNAs IN DEVELOPMENT AND DISEASE: BACKGROUND, MECHANISMS, AND THERAPEUTIC APPROACHES
Julia Beermann et al.
PHYSIOLOGICAL REVIEWS (2016)
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay et al.
SCIENCE SIGNALING (2016)
Circular RNA Expression: Its Potential Regulation and Function
Julia Salzman
TRENDS IN GENETICS (2016)
Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk
Rastislav Tamaskovic et al.
NATURE COMMUNICATIONS (2016)
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
Klaus Okkenhaug et al.
CANCER DISCOVERY (2016)
Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer
Xiuning Le et al.
CANCER DISCOVERY (2016)
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay et al.
SCIENCE SIGNALING (2016)
Application of SELDI-TOF in N-glycopeptides profiling of the urine from patients with endometrial, ovarian and cervical cancer
Alan Kang-Wai Mu et al.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2016)
Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABABR-mediated chemotaxis
Michelle T. Barati et al.
CELLULAR SIGNALLING (2015)
Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling
Hongzhao Li et al.
CELLULAR SIGNALLING (2015)
Cancer biomarker detection: recent achievements and challenges
Li Wu et al.
CHEMICAL SOCIETY REVIEWS (2015)
Osteosarcoma: Current Treatment and a Collaborative Pathway to Success
Michael S. Isakoff et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
The PI3K/AKT Pathway and Renal Cell Carcinoma
Huifang Guo et al.
JOURNAL OF GENETICS AND GENOMICS (2015)
Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin
Matthew G. Oser et al.
LANCET ONCOLOGY (2015)
A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study
Xue-Jia Lin et al.
LANCET ONCOLOGY (2015)
Principles in the design of ligand-targeted cancer therapeutics and imaging agents
Madduri Srinivasarao et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Exon-intron circular RNAs regulate transcription in the nucleus
Zhaoyong Li et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Exon-intron circular RNAs regulate transcription in the nucleus
Zhaoyong Li et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Non-small-cell lung cancer
Cesare Gridelli et al.
NATURE REVIEWS DISEASE PRIMERS (2015)
Genetic mutations in sporadic pituitary adenomas-what to screen for?
Anne-Lise Lecoq et al.
NATURE REVIEWS ENDOCRINOLOGY (2015)
Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy
Jieli Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)
RAS interaction with P13K p110α is required for tumor-induced angiogenesis
Miguel Manuel Murillo et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
The genomic landscape of hepatoblastoma and their progenies with HCC-like features
Melanie Eichenmüller et al.
JOURNAL OF HEPATOLOGY (2014)
Detecting and characterizing circular RNAs
William R. Jeck et al.
NATURE BIOTECHNOLOGY (2014)
PDK1 controls upstream PI3K expression and PIP3 generation
A. M. Dieterle et al.
ONCOGENE (2014)
CIP2A regulates cell proliferation via the AKT signaling pathway in human lung cancer
Ningjing Lei et al.
ONCOLOGY REPORTS (2014)
Activated α2-Macroglobulin Binding to Cell Surface GRP78 Induces T-Loop Phosphorylation of Akt1 by PDK1 in Association with Raptor
Uma Kant Misra et al.
PLOS ONE (2014)
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses
Carol Dangelmaier et al.
THROMBOSIS AND HAEMOSTASIS (2014)
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy
He Huang et al.
AUTOPHAGY (2013)
Potential Role of Genetic Markers in the Management of Kidney Cancer
Kerstin Junker et al.
EUROPEAN UROLOGY (2013)
Circular Intronic Long Noncoding RNAs
Yang Zhang et al.
MOLECULAR CELL (2013)
VIEWPOINT Increasing incidence of thyroid cancer: controversies explored
Yasuhiro Ito et al.
NATURE REVIEWS ENDOCRINOLOGY (2013)
Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes
Satoko Ishikawa et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)
Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain
Bianca T. Hofmann et al.
CELLULAR SIGNALLING (2012)
Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
C. Johnson et al.
GENES BRAIN AND BEHAVIOR (2012)
Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeutics
W. Marston Linehan
GENOME RESEARCH (2012)
Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1
Jorgelina M. Calandria et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Adult hepatoblastoma: Learning from children
Anne-Laure Rougemont et al.
JOURNAL OF HEPATOLOGY (2012)
The genetic architecture of multiple myeloma
Gareth J. Morgan et al.
NATURE REVIEWS CANCER (2012)
Advances in surgical therapy for thyroid cancer
Haggi Mazeh et al.
NATURE REVIEWS ENDOCRINOLOGY (2011)
Thyroid cancer stem cells
Reigh-Yi Lin
NATURE REVIEWS ENDOCRINOLOGY (2011)
PI3K/AKT/mTOR pathway in angiogenesis
Jayashree Karar et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)
Targeting Fibroblast Growth Factor Receptors Blocks PI3K/AKT Signaling, Induces Apoptosis, and Impairs Mammary Tumor Outgrowth and Metastasis
Julien H. Dey et al.
CANCER RESEARCH (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Familial pituitary tumor syndromes
Marianne S. Elston et al.
NATURE REVIEWS ENDOCRINOLOGY (2009)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor - Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma
Silvia Montaner
CELL CYCLE (2007)
Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K
Yeun-Kyung Shin et al.
JOURNAL OF GENERAL VIROLOGY (2007)
Serum and glucocorticoid-regulated protein kinases: Variations on a theme
Maude Tessier et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
PI3K/Akt signalling pathway and cancer
JAF Vara et al.
CANCER TREATMENT REVIEWS (2004)
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
GY Oudit et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
Protein kinase C βII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
Y Kawakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes
RC Hresko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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