19F MRI Probes for Multimodal Imaging**

Magnetic resonance imaging (MRI) is one of the most powerful imaging tools today, capable of displaying superior soft-tissue contrast. This review discusses developments in the field of F-19 MRI multimodal probes in combination with optical fluorescence imaging (OFI), H-1 MRI, chemical exchange saturation transfer (CEST) MRI, ultrasonography (USG), X-ray computed tomography (CT), single photon emission tomography (SPECT), positron emission tomography (PET), and photoacoustic imaging (PAI). In each case, multimodal F-19 MRI probes compensate for the deficiency of individual techniques and offer improved sensitivity or accuracy of detection over unimodal counterparts. Strategies for designing F-19 MRI multimodal probes are described with respect to their structure, physicochemical properties, biocompatibility, and the quality of images.

Automated summary

This review discusses the development of F-19 MRI multimodal probes in combination with various imaging techniques, highlighting how they compensate for deficiencies in individual techniques and improve sensitivity and accuracy of detection. Strategies for designing these probes focus on structure, physicochemical properties, biocompatibility, and image quality.