期刊
FISH AND SHELLFISH IMMUNOLOGY REPORTS
卷 2, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fsirep.2021.100020
关键词
Thrombospondin; Penaeus monodon; WSSV; immunostimulants; beta-glucan
资金
- Department of Science and Technology, Government of India [DST/INT/Belg/P-03/2014]
- Indian Council of Agricultural Research (ICAR), through the NBSFARA project, Government of India [NFBSFARA/BS-3016/2012-13]
Thrombospondins are important glycoproteins that play crucial roles in cell homeostasis, wound healing, angiogenesis, and more. Their role in shrimp immunity is still not well understood, but studies show that their expression is significantly upregulated in shrimp tissues when exposed to white spot syndrome virus (WSSV). This suggests that Thrombospondins may act as an inducible acute phase response protein to WSSV infection.
Thrombospondins (TSPs) are extracellular, calcium-binding glycoproteins that play an essential role in cell homeostasis and development, wound-healing, angiogenesis, connective tissue organization, immune response etc. and it conserves from sea sponges to mammals. However, their role in shrimp immunity is poorly under-stood. In the present study, the differential expression profiling of TSP transcripts in Penaeus monodon tissues such as gills, lymphoid organs, hepatopancreas, and hemolymph challenged with white spot syndrome virus (WSSV), were studied by quantitative real-time PCR. Further, shrimps fed with the immunostimulant (beta-glucan) when challenged with WSSV showed significant upregulation of TSP expression in gills, hepatopancreas, and lymphoid organ at the early phase of WSSV infection. The results suggest that TSP may be an inducible acute phase response protein to WSSV infection. The possibility of differences in mRNA expression pattern seen in immunostimmulated shrimp after the viral challenge, possibility due to altered immune mechanisms getting triggered during immunostimulant administration and virus infections in the host.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据