Stille, Heck, and Sonogashira coupling and hydrogenation catalyzed by porous-silica-gel- supported palladium in batch and flow

Owing to their recyclability, heterogeneous transition metal catalysts represent a means of conserving depletable resources for the synthesis of pharmaceutical, agricultural, and functional chemicals. We recently developed a novel heterogeneous palladium catalyst and demonstrated its synthetic availability for Suzuki-Miyaura cross-coupling. Herein, we report the further application of the present catalyst to cross-coupling reactions in batch and flow, as well as a hydrogenative reduction reaction in flow. We demonstrate the flow synthesis for useful material, a liquid crystal, and a 1 h sequential operation of the coupling reaction and hydrogenation reaction.

Automated summary

This study introduces a novel heterogeneous palladium catalyst for Suzuki-Miyaura cross-coupling and demonstrates its synthetic availability in batch and flow reactions. The research also includes the application of this catalyst in hydrogenative reduction reactions in flow, showcasing a sequential operation of coupling and hydrogenation reactions within 1 hour.