Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

Editorial Material Critical Care Medicine

Multisystem Inflammatory Syndrome in Adults Coming Into Focus

Mark W. Tenforde et al.

CHEST (2021)

Article Cardiac & Cardiovascular Systems

Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol

Jose Manuel Condor Capcha et al.

Summary: Studying the viral entry mechanisms of SARS-CoV-2 is crucial for developing therapeutic approaches for COVID-19, and a simple and effective method has been developed for producing pseudoviruses carrying the SARS-CoV-2 spike, suitable for studying viral infection in various cell lines.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Immunology

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series

Julu Bhatnagar et al.

Summary: This study identified cellular targets of SARS-CoV-2 tropism and replication in various tissues, showing direct infection in the lungs and airways. The research provides important insights into COVID-19 pathogenesis and mechanisms of severe outcomes.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Immunology

Multisystem inflammatory syndrome in children and adults (MIS-C/A): definition & guidelines for data collection, analysis, and presentation of immunization safety data

Tiphanie P. Vogel et al.

Summary: This article presents a Brighton Collaboration Case Definition for Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A) for evaluating adverse events following immunization. Developed by topic experts convened by CEPI, the case definition underwent extensive literature review and peer review before publication.

VACCINE (2021)

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Article Immunology

Multisystem Inflammatory Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccination

Mark B. Salzman et al.

Summary: This report discusses 3 cases of patients in California who experienced multisystem inflammatory syndrome (MIS) after receiving vaccination and being infected with SARS-CoV-2. It also mentions 3 cases of adults who were not vaccinated developing MIS during a period when around 7% of the adult population had received at least one vaccine.

EMERGING INFECTIOUS DISEASES (2021)

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Article Medical Laboratory Technology