Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

We describe a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination. The immunopathology of this syndrome, regardless of vaccination status, remains poorly understood.

Automated summary

This case describes a fatal instance of multisystem inflammatory syndrome in an adult occurring 22 days after receiving the second dose of an mRNA coronavirus vaccine. Both serologic and clinical findings suggested the infection of SARS-CoV-2 happened before the vaccination. The immunopathology of this syndrome, regardless of vaccination status, is still poorly understood.