期刊
BMB REPORTS
卷 54, 期 11, 页码 569-574出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2021.54.11.089
关键词
Bombesin-like peptides; Neuromedin B; Neuromedin B receptor; Vascular calcification; Vascular smooth muscle cells
资金
- National Research Foundation of Korea - Korean government (MSIT) [NRF-2018R1A5A2023879]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2019R1I1A1A01061377]
The study found that in phosphate-induced vascular smooth muscle cell calcification, the expression of neuromedin B and NMB receptor is upregulated, suggesting the potential therapeutic value of the NMB-NMB receptor axis.
Vascular calcification is the heterotopic accumulation of calcium phosphate salts in the vascular tissue and is highly correlated with increased cardiovascular morbidity and mortality. In this study, we found that the expression of neuromedin B (NMB) and NMB receptor is upregulated in phosphate-induced calcification of vascular smooth muscle cells (VSMCs). Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/beta-catenin signaling and VSMC apoptosis. PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. The results of this study suggest that NMB-NMB receptor axis may have potential therapeutic value in the diagnosis and treatment of vascular calcification.
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