期刊
EPILEPSIA
卷 59, 期 2, 页码 369-380出版社
WILEY
DOI: 10.1111/epi.13972
关键词
continuous hippocampal stimulation; death; status epilepticus; temporal lobe epilepsy
资金
- National Institute of Neurological Disorders and Stroke [RO1 NS 040337, RO1 NS 044370]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044370, R01NS040337] Funding Source: NIH RePORTER
ObjectiveTo characterize the evolution of behavioral and electrographic seizures in an experimental electrical stimulation-based model of status epilepticus (SE) in C57Bl/6 mice, and to relate SE to various outcomes, including death and epileptogenesis. MethodsSE was induced by continuous hippocampal stimulation and was evaluated by review of electroencephalographic recordings, spectral display, and behavior. ResultsSeizures were initially locked to the electrical trains but later became independent of them. Following the end of stimulation, autonomous seizures continued for >5 minutes in 85% of the animals. There was ongoing 2-3-Hz rhythmic, high-amplitude, slow spike-wave discharges (HASDs) associated with purposeless, repetitive, continuously circling and exploratory behavior. There were high-amplitude fast discharges (HAFDs) associated with worsening of behavioral seizures that were interspersed with the ongoing HASDs. Death during SE occurred in 23% of the animals, and it was preceded by a stage 5 behavioral seizure. In the waning stage of SE, severe seizures and HAFDs dissipated, HASDs slowed down, and normal behavior was restored in most animals. Epilepsy developed in 33% of the animals monitored after SE. SignificanceThe electrical stimulation model of SE can be used to study mechanisms of SE and its adverse consequences, including death and epileptogenesis.
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