期刊
MEDICINA-LITHUANIA
卷 57, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/medicina57111171
关键词
semantic dementia; Alzheimer's disease; semantic memory; free associations
资金
- Italian Ministry of Health
The study introduces a new easily administered task to differentiate between semantic dementia and Alzheimer's disease patients based on semantic tasks. By contrast F-Assoc with verbal fluency tasks, a clear discrepancy pattern was observed between SD and AD patients. The study also validates the asymmetry measure between F-Assoc and Cat-FL as an index of control impairment.
Backround and Objectives: It is widely agreed that patients suffering from Alzheimer's disease (AD) and patients suffering from semantic dementia (SD) might fail clinically administered semantic tasks due to a different combination of underlying cognitive deficits: namely, degraded semantic representations in SD and degraded representations plus executive control deficit in AD. However, no easy administrable test or test battery for differentiating the semantic impairment profile in these populations has been devised yet. Materials and Methods: In this study, we propose a new easy administrable task based on a free association procedure (F-Assoc) to be used in conjunction with category fluency (Cat-Fl) and letter fluency (Lett-Fl) for quantifying pure representational and pure control deficits, thus teasing apart the semantic profile of SD and AD patients. Results: In a sample of 10 AD and 10 SD subjects, matched for disease severity, we show that indices of asymmetric performance contrasting F-Assoc and each of the two verbal fluency tasks yield a clearly distinguishable discrepancy pattern across SD and AD. We also provide empirical support for the validity of an asymmetry measure contrasting F-Assoc and Cat-FL as an index of control impairment. Conclusions: The present study suggests that the free association procedure provides a pure measure of degradation of semantic representations avoiding the confound of possible concomitant executive deficits.
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