期刊
EPIGENETICS
卷 12, 期 5, 页码 353-369出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15592294.2016.1278095
关键词
Acetylation; brain tumor; demethylase; DIPG; epigenetic; histone; methylation; methyltransferase; pediatric
资金
- US National Institutes of Health (NIH) [NS093079]
- Bear Necessities Pediatric Cancer Foundation
- Rally Foundation
- John McNicholas Pediatric Brain Tumor Foundation
Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.
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