期刊
ANNALS OF BEHAVIORAL MEDICINE
卷 55, 期 12, 页码 1253-1261出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/abm/kaab015
关键词
Side-effects; Expectations; Predictors; Nocebo effect
资金
- National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emergency Preparedness and Response [NIHR200890]
Research on predictors of side-effect expectations found that younger, White individuals with lower optimism and increased anxiety were more likely to expect warned side-effects, while those with lower trust in medicine development were more likely to expect unwarned side-effects. Additionally, individuals with higher somatization, baseline symptoms, modern health worries, and lower trust in pharmaceutical companies were more likely to expect all side-effects. There is a need for further investigation in patient samples where the medication is known to them.
Background Research investigating predictors of side-effect expectations is disparate and largely based on hypothetical vignettes. Purpose To carry out a secondary analysis of a randomized controlled trial and investigate the predictors of side-effect expectations for side-effects that were, or were not, warned about. Methods Two hundred and three healthy adults completed measures concerning demographics, psychological factors, baseline symptoms, and medication-related beliefs before reading one of two types of patient information leaflet (PIL) (standard or positively framed PIL) for a sham medication and asking them about their side-effect expectations. Associations between these measures and side-effect expectations whilst controlling for the PIL received were assessed using regression analyses. Results 82.8% of participants expected side-effects that were warned about in the PIL, and 29.1% expected side-effects that were not warned about. Participants who were younger, from White backgrounds, less optimistic, experienced increased anxiety and received the standard PIL were more likely to expect side-effects that were warned about. Those with higher beliefs about medicine overuse and lower trust in medicine development were more likely to expect side-effects that were not warned about. Higher somatization, baseline symptoms, modern health worries scores, and lower trust in pharmaceutical companies were associated with increased expectations for all side-effects. The results suggest we can not only rely on altering side-effect risk communication to reduce side-effect expectations and therefore nocebo effects. We must also consider patients' beliefs about trust in medicines. More work is needed to investigate this in a patientsample in which the medication is known to them.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据