期刊
JOURNAL OF VETERINARY SCIENCE
卷 22, 期 6, 页码 -出版社
KOREAN SOC VETERINARY SCIENCE
DOI: 10.4142/jvs.2021.22.e74
关键词
Tissue engineering; mesenchymal stem cells; bone marrow mesenchymal stem cells; stemness characteristics
资金
- Faculty of Veterinary Science
- Chulalongkorn Academic Advancement into Its 2nd Century Project
- Veterinary Stem Cell and Bioengineering Research Unit, Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University
- Government Research Fund
- First International Conference of Advanced Veterinary Science and Technologies for Sustainable Development (ICAVESS) on April 28-29 2021 in Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
This review compares and summarizes the growth kinetics and stemness properties of bone marrow MSCs in different animal species and humans, as well as provides current information on the use of BM-MSCs in clinical practice.
Tissue engineering has been extensively investigated and proffered to be a potential platform for novel tissue regeneration. The utilization of mesenchymal stem cells (MSCs) from various sources has been widely explored and compared. In this regard, MSCs derived from bone marrow have been proposed and described as a promising cell resource due to their high yield of isolated cells with colony-forming potential, self-renewal capacity, MSC surface marker expression, and multi-lineage differentiation capacities in vitro. However, there is evidence for bone marrow MSCs (BM-MSCs) both in vitro and in vivo from different species presenting identical and distinct potential stemness characteristics. In this review, the fundamental knowledge of the growth kinetics and stemness properties of BM-MSCs in different animal species and humans are compared and summarized. Finally, to provide a full perspective, this review will procure results of current information studies focusing on the use of BM-MSCs in clinical practice.
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