4.4 Article

Toxicity Assessment of Dibutyl Phthalate in Grass Carp: An Integrated Biomarker Approach

期刊

PAKISTAN VETERINARY JOURNAL
卷 41, 期 3, 页码 365-371

出版社

UNIV AGRICULTURE, FAC VETERINARY SCIENCE
DOI: 10.29261/pakvetj/2021.031

关键词

Dibutyl Pthalate; Grass carp; Oxidative stress; Phthalates

资金

  1. ORIC
  2. GCU
  3. European Union
  4. Welsh Government
  5. Cardiff University

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The study evaluated the toxic effects of DBP on grass carp, showing oxidative stress and damage to the liver and kidney. Integrated biomarker response analysis demonstrated that the most impacted organ was the kidney, followed by the liver and gills. Further research is needed to understand the effects of DBP on different organs in fish.
Phthalates are the common plasticisers used around the globe. Dibutyl phthalate (DBP) is a ubiquitous, extensively used in cosmetics and frequently present in the aquatic environment. Therefore, toxic effects of DBP were evaluated in terms of oxidative stress and biochemical biomarkers. For this reason, a 21-day exposure was conducted by exposing grass carp with graded concentrations of DBP (1, 10, 100 and 1000 mu g/L). After 21days, stress biomarkers: lipid peroxidation (LPO), catalase (CAT) activity, glutathione-S-transferases (GST) activity and level of reduced glutathione were evaluated in liver, kidney and gills. Alkaline phosphatase (ALP), aspartate transaminase (AST), urea and creatinine were evaluated in liver and kidney homogenates respectively. Moreover, effect of DBP on all biomarkers were evaluated through integrated biomarker response (IBR). Exposure of fish to DBP resulted in oxidative stress in grass carp as evidenced by an increase in lipid peroxidation and decrease in antioxidant enzymes. DBP exposure also resulted in increased liver's ALT and AST levels. Urea and creatinine were also significantly increased in kidney after exposure to DBP. The IBR showed bad scores as the DBP concentration increased, with the highest one (1000 mu g/L) presenting a score >250x the value for the control treatment. Additionally, the IBR/n showed that the most impacted organ was the kidney, followed by the liver and the gills. The obtained results show the need for deeper research into the effects of DBP on fish and their impact on different organs. (c) 2021 PVJ. All rights reserved

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