期刊
STAR PROTOCOLS
卷 2, 期 4, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.xpro.2021.100951
关键词
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资金
- National Institutes of Health (NIH) [F32DK130248]
- American Academy of Pediatrics Marshall Klaus Award
- NIH [R01DK118568, R01DK124614, R01HD105301]
- St. Louis Children's Hospital Foundation
- Children's Discovery Institute of Washington University and St. Louis Children's Hospital
- Department of Pediatrics at Washington University School of Medicine, St. Louis
- Takeda Pharmaceuticals
- Evive Biotech
Recapitulating human NEC using animal models has provided valuable insights into the disease pathology and potential therapeutic strategies. This in vivo murine NEC model using hypoxia and enteric bacteria aims to further dissect NEC pathogenesis and develop new treatments. For the full protocol details, please refer to Mihi et al. (2021).
Recapitulating human NEC using animal models has been insightful in dissecting the signaling pathways, immune-mediated mechanisms, genetic signatures, and the intestinal architecture of NEC. This protocol describes an in vivo murine NEC model, using hypoxia and formula containing lipopolysaccharide and enteric bacteria derived from an infant with NEC. With this mouse model, we aim to further dissect NEC pathogenesis and develop new therapeutic strategies. For complete details on the use and execution of this protocol, please refer to Mihi et al. (2021).
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