Reciprocal regulation of IgA and the gut microbiota: a key mutualism in the intestine

The mammalian intestine is home to trillions of microbes, and their colonization contributes to host physiology through the production of indispensable metabolites and competition against pathogens. However, it is also important to balance this symbiotic relationship, as overgrowth and translocation of microbes could trigger a fatal infection. IgA is the major immunoglobulin class produced and secreted in the intestine and is considered to play a pivotal role in maintaining homeostasis. In this review, we summarize recent studies exploring the interactions between IgA and the gut microbiota and explain how different types of IgA could coexist to regulate the gut microbiota. In particular, we discuss two important aspects of IgA in controlling the gut microbes: function and specificity. Differences in these two aspects appear attributable to how IgA is induced and are associated with the functions of IgA as well. Together, our review delineates a recent understanding of IgA-microbiome interactions and proposes a future direction to clarify its complexity.

Automated summary

This review summarizes recent studies on the interaction between intestinal immunoglobulin IgA and gut microbiota, discussing the coexistence of different types of IgA to regulate gut microbiota and emphasizing the importance of IgA function and specificity in controlling gut microbes. Differences in these aspects are associated with how IgA is induced, contributing to a better understanding of IgA-microbiome interactions and potential future directions for clarification of this complexity.