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Tunisian inland water microflora as a source of phycobiliproteins and biological activity with beneficial effects on human health

期刊

OCEANOLOGICAL AND HYDROBIOLOGICAL STUDIES
卷 50, 期 4, 页码 385-397

出版社

WALTER DE GRUYTER GMBH
DOI: 10.2478/ohs-2021-0033

关键词

Tunisian inland water; microalgae identification; phytochemical content; biological activity

资金

  1. Laboratoire Ecosystemes et Ressources Aquatiques et Animales, Institut National Agronomique de Tunisie, University of Carthage
  2. Bioactive Substances Laboratory, Biotechnology Center of Borj-Cedria, Tunisia
  3. Ministry of Higher Education and Scientific Research of the Tunisian government

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This study isolated ten monoclonal microalgal cultures from Tunisian inland water bodies and identified several with potential antioxidant, antibacterial, antileishmanial activity, and high phycobiliprotein production. Some strains showed high activity, indicating promising potential as new antioxidants, phycocyanin sources, and candidates for leishmaniasis treatment.
Ten monoclonal microalgal cultures were obtained from several Tunisian inland water bodies, and their dichloromethane and methanolic extracts were screened for antibacterial, antileishmanial, and antioxidant properties, as well as phycobiliprotein production capacity. Cylindrospermopsis raciborskii has been shown to synthesize high levels of phycocyanin and may be an effective alternative source to other sources used for commercial production of phycocyanin. Chroococcus sp. and Leptolyngbya sp1. exhibited the strongest radical scavenging activity against DPPH (IC50 = 212.15 and 263.91 mu g ml(-1,) respectively), indicating their promising potential for use as new effective and non-toxic antioxidants. Furthermore, Dunaliella sp. showed an interesting antileishmanial activity against the pathogens Leishmania infantum and Leishmania major (IC50 = 151 and 284 mu g ml(-1), respectively), thus representing a good candidate for use against cutaneous and visceral leishmaniasis in Tunisia, a country endemic to these diseases where thousands of new cases are registered every year. These results suggest that the strains of microalgae featured in this work have the potential to serve as natural alternative, safe and sustainable sources of high value-added products that could be used to improve the final biomass value.

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