4.4 Article

Galectin-3 plays a protective role in Leishmania (Leishmania) amazonensis infection

期刊

GLYCOBIOLOGY
卷 31, 期 10, 页码 1378-1389

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwab062

关键词

galectin-3; Leishmania (L.) amazonensis; parasitophorous vacuole; PRR; DAMP

资金

  1. Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  3. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)

向作者/读者索取更多资源

The study revealed the critical role of gal-3 in the host response to infection by L. (L.) amazonensis, controlling parasite invasion, replication, and formation of endocytic vesicles. Mice with gal-3 deficiency showed an exacerbated inflammatory response.
Leishmania (L.) amazonensis is one of the species responsible for the development of cutaneous leishmaniasis in South America. After entering the vertebrate host, L. (L.) amazonensis invades mainly neutrophils, macrophages and dendritic cells. Studies have shown that gal-3 acts as a pattern recognition receptor. However, the role of this protein in the context of L. (L.) amazonensis infection remains unclear. Here, we investigated the impact of gal-3 expression on experimental infection by L. (L.) amazonensis. Our data showed that gal-3 plays a role in controlling parasite invasion, replication and the formation of endocytic vesicles. Moreover, mice with gal-3 deficiency showed an exacerbated inflammatory response. Taken together, our data shed light to a critical role of gal-3 in the host response to infection by L. (L.) amazonensis.

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