期刊
SEMINARS IN IMMUNOLOGY
卷 53, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2021.101527
关键词
Type 2 immunity; Maternal; Offspring; Helminth; Allergy; Pregnancy; In utero; Lactation; Regulatory immunity; Microbiome; Microchimersim
类别
资金
- NRF/FNRS grant [120328]
- BACTIVAC grant [27506]
- BBSRC [BB/S002987]
- Darwin Trust Edinburgh PhD Fellowship
- Scarbrow Bursary Fund
- Wellcome Trust [203135/Z/16/Z]
An inherent elevation in type 2 immunity is a feature of maternal and offspring immune systems, influencing pregnancy success, offspring immune development, and ability to control infections and diseases such as allergies. Understanding this axis of immune influence can be utilized to improve maternal and offspring health.
An inherent elevation in type 2 immunity is a feature of maternal and offspring immune systems. This has diverse implications for maternal and offspring biology including influencing success of pregnancy, offspring immune development and maternal and offspring ability to control infection and diseases such as allergies. In this review we provide a broad insight into how this immunological feature of pregnancy and early life impacts both maternal and offspring biology. We also suggest how understanding of this axis of immune influence is and may be utilised to improve maternal and offspring health.
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