期刊
CURRENT RESEARCH IN FOOD SCIENCE
卷 4, 期 -, 页码 336-344出版社
ELSEVIER
DOI: 10.1016/j.crfs.2021.05.002
关键词
Alpha-lipoic acid; Acetyl-L-carnitine; Nutraceutical; Antioxidant; Pilot study
资金
- European Union [816303]
- Plan propio de Investigacion y Transferencia of the University of Granada under the program Intensificacion de la Investigacion, modalidad B
- Spanish predoctoral fellowship F.P.U. from the Spanish Ministry of Science, Innovation and Universities [18/06440]
The study evaluated the antioxidant and metabolic effects of a dietary supplement based on ALA and ALC, finding significant preventive effects against oxidative stress and recommending 2 capsules as a reasonable dosage.
Personalized nutrition (PN) is seen as a potentially effective and affordable strategy for the prevention of non-communicable diseases (NCDs). In this study we aimed to evaluate the antioxidant and metabolic effect of a dietary supplement based on alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) in order to include this product in a novel PN service. The antioxidant properties of the commercial nutraceutical were investigated at physiological conditions (through in vitro digestion) and at mitochondrial conditions. The metabolic activity was assessed in a human pilot study using a Gas Chromatography-Mass Spectrometry (GC-MS) methodology in dried urine samples. The nutraceutical exerted an elevated antiradical activity and reducing capacity, especially at mitochondrial conditions, after in vitro digestion. This increase in mitochondrial activity was also evidenced in vivo by a significant increase in the urinary phosphate concentration (p = 0.004). As pro-oxidant effect was reached with the concentration of 4 capsules, 2 capsules at the same time could be a reasonable dose. No adverse effects were recorded in vivo with this dose. Thus, although its metabolic effect was not so conclusive, ALA thorn ALC combination might be beneficial as a dietary supplement for the prevention of the oxidative stress and an interesting dietary supplement to consider in large scale studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据