4.4 Review

Helicobacter pylori diagnosis and therapy in the era of antimicrobial stewardship

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Review Gastroenterology & Hepatology

Primer for Development of Guidelines for Helicobacter pylori Therapy Using Antimicrobial Stewardship

David Y. Graham et al.

Summary: This article provides guidance on transitioning Helicobacter pylori therapy guidelines to adhere to the principles of antimicrobial stewardship. The goals of antimicrobial stewardship are optimizing antibiotic use and reducing resistance. Only therapies with at least a 90% cure rate should be considered acceptable. The article also emphasizes the importance of surveillance and recommends treatment guidelines consistent with ASID white paper.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Medicine, General & Internal

Molecular detection of Helicobacter pylori and clarithromycin resistance in gastric biopsies: a prospective evaluation of RIDA®GENE Helicobacter pylori assay

Bea Van den Poel et al.

Summary: The study evaluated the RIDA (R) GENE Helicobacter pylori assay for detecting H. pylori and clarithromycin resistance mutations in gastric biopsies, showing high sensitivity and specificity compared to culture and IHCS. This assay proves reliable and rapid for detecting H. pylori and its clarithromycin resistance in human gastric biopsies.

ACTA CLINICA BELGICA (2021)

Article Gastroenterology & Hepatology

European Registry on Helicobacter pylori management (Hp--EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients

Olga P. Nyssen et al.

Summary: The study aimed to evaluate the decision-making and outcomes in Helicobacter pylori management by European gastroenterologists, finding that management of H. pylori infection is heterogeneous, with only quadruple therapies able to achieve over 90% eradication rates, and European recommendations are slowly and heterogeneously being incorporated into routine clinical practice.
Review Gastroenterology & Hepatology

Vonoprazan-containingHelicobacter pyloritriple therapies contribution to global antimicrobial resistance

David Y. Graham et al.

Summary: The combination therapy of amoxicillin and proton pump inhibitor for H. pylori treatment is not highly effective due to the inability to maintain a high intragastric pH. Clarithromycin resistance has led to treatment failures, impacting the efficacy of various dual and triple therapies. Optimized vonoprazan-amoxicillin dual therapy has shown to achieve cure rates >= 95%, highlighting the importance of developing antimicrobial stewardship practices for efficient treatment strategies without overuse of antibiotics.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

Review Microbiology

Rifabutin for the Treatment of Helicobacter pylori Infection: A Review

Javier P. Gisbert

Summary: Rifabutin-containing therapy has shown promising results in the management of Helicobacter pylori infection, with relatively low resistance rates and infrequent adverse events. It is a recommended strategy for patients with previous treatment failures.

PATHOGENS (2021)

Article Gastroenterology & Hepatology

Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for Helicobacter pylori Infection: A Network Meta-analysis

Theodore Rokkas et al.

Summary: The study compared the effectiveness of different first-line regimens for Helicobacter pylori infection through a network meta-analysis. Results showed that vonoprazan triple therapy and reverse hybrid therapy achieved high eradication rates above 90%, with levofloxacin triple therapy performing best in Western countries. Standard triple therapy was found to be the least efficacious in this analysis.

GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

AGA Clinical Practice Update on the Management of Refractory Helicobacter pylori Infection: Expert Review

Shailja C. Shah et al.

Summary: The purpose of this CPU Expert Review is to provide clinicians with guidance on the management of Helicobacter pylori after initial eradication therapy failure. The review is not formal systematic, but based on literature to provide practical advice. The strength or quality of the evidence was not formally rated, instead a combination of available evidence and consensus-based expert opinion were used to develop best practice advice.

GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

PPI-amoxicillin dual therapy four times daily is superior to guidelines recommended regimens in the Helicobacter pylori eradication therapy within Asia: A systematic review and meta-analysis

Cailing Li et al.

Summary: PPI-amoxicillin dual therapy administered four-times daily has shown better efficacy and safety in H. pylori eradication compared to other regimens, especially in first-line therapy and primarily in Asia.

HELICOBACTER (2021)

Article Medicine, General & Internal

Rifabutin-Based Triple Therapy (RHB-105) for Helicobacter pylori Eradication A Double-Blind, Randomized, Controlled Trial

David Y. Graham et al.

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S1348 Triple Therapy for Primary Treatment of Helicobacter pylori: A 19-Year U.S. Single Center Experience

Brian D. Ginnebaugh et al.

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Migration and tuberculosis in Europe

D. A. Boudville et al.

JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES (2020)

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Impact of Previous Exposure to Macrolide Antibiotics on Helicobacter pylori Infection Treatment Outcomes

Doron Boltin et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

Review Gastroenterology & Hepatology

Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing

Daniel Pohl et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Review Gastroenterology & Hepatology

Interchangeable Use of Proton Pump Inhibitors Based on Relative Potency

David Y. Graham et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Houston Consensus Conference on Testing for Helicobacter pylori Infection in the United States

Hashem B. El-Serag et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

Editorial Material Gastroenterology & Hepatology

Update on the Use of Vonoprazan: A Competitive Acid Blocker

David Y. Graham et al.

GASTROENTEROLOGY (2018)

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Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases

Tadayuki Oshima et al.

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Understanding treatment guidelines with bismuth and non-bismuth quadruple Helicobacter pylori eradication therapies

David Y. Graham et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2018)

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Failure of optimized dual proton pump inhibitor amoxicillin therapy: What now?

David Y. Graham et al.

SAUDI JOURNAL OF GASTROENTEROLOGY (2017)

Review Gastroenterology & Hepatology

Furazolidone, an Underutilized Drug for H-pylori Eradication: Lessons from Iran

Marjan Mohammadi et al.

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The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use

Sun Gyo Lim et al.

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Role of bismuth in improving Helicobacter pylori eradication with triple therapy

Maria Pina Dore et al.

Article Gastroenterology & Hepatology

Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples

Denise E. Brennan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Gastroenterology & Hepatology

Antibiotic Resistance of Helicobacter pylori Among Male United States Veterans

Seiji Shiota et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

Potent Gastric Acid Inhibition Over 24 Hours by 4-Times Daily Dosing of Esomeprazole 20 mg

Shu Sahara et al.

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How to Effectively Use Bismuth Quadruple Therapy: The Good, the Bad, and the Ugly

David Y. Graham et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2015)

Article Gastroenterology & Hepatology

Kyoto global consensus report on Helicobacter pylori gastritis

Kentaro Sugano et al.

Article Infectious Diseases

Heteroresistance of Helicobacter pylori from the same patient prior to antibiotic treatment

Cheng-Yen Kao et al.

INFECTION GENETICS AND EVOLUTION (2014)

Article Gastroenterology & Hepatology

Is Helicobacter pylori antibiotic resistance surveillance needed and how can it be delivered?

C. A. M. McNulty et al.

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Adherence to Medications: Insights Arising from Studies on the Unreliable Link Between Prescribed and Actual Drug Dosing Histories

Terrence F. Blaschke et al.

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Helicobacter pylori molecular diagnosis

Philippe Lehours et al.

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Helicobacter pylori Therapy Demystified

David Y. Graham et al.

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Pharmacologic Aspects of Eradication Therapy for Helicobacter pylori Infection

Takahisa Furuta et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2010)

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Helicobacter pylori treatment in the era of increasing antibiotic resistance

David Y. Graham et al.

Article Gastroenterology & Hepatology

Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States

David Y. Graham et al.

JOURNAL OF GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths

David Y. Graham et al.

JOURNAL OF DIGESTIVE DISEASES (2009)

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New concepts of resistance in the treatment of Helicobacter pylori infections

David Y. Graham et al.

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY (2008)

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Persister cells, dormancy and infectious disease

Kim Lewis

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Drug therapy - Adherence to medication

L Osterberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Meta-analysis:: the efficacy, adverse events, and adherence related to first-line anti-Helicobacter pylori quadruple therapies

LA Fischbach et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2004)

Article Pharmacology & Pharmacy

Management of Helicobacter pylori eradication -: the influence of structured counselling and follow-up

FA Al-Eidan et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)

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Pathogenesis of increased sucrose permeability in H-pylori gastritis

DY Graham

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