期刊
AGING-US
卷 13, 期 23, 页码 25213-25240出版社
IMPACT JOURNALS LLC
关键词
miR-338-5p; circRNA; IKBIP; ceRNA; glioma
资金
- Science and Technology Program of Shenzhen [GJHZ20190821161601670]
- Jinan University
- Shenzhen People's Hospital
The study identified miR-338-5p as a suppressor of glioma development and predicted that multiple circRNAs could relieve the silencing of IKBIP, potentially affecting glioma progression. This provides new insights for investigating ceRNAs in glioma.
Glioma is a primary intracranial tumor with high morbidity and mortality. We acquired miR-338-5p, which suppresses the development of glioma, from the GEO and CGGA databases. In addition, we predicted that hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 could relieve the silencing of IKBIP by miR-338-5p. By analyzing genes related to IKBIP expression, possible pathways affecting glioma were identified. This study provides new ideas for investigating multiple circRNAs in ceRNAs.
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