期刊
RESPIRATORY RESEARCH
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12931-021-01919-1
关键词
Human microbiome; Taxonomy; Lung cancer; PD-L1 expression levels
资金
- National Research Foundation of Korea [2018R1C1B5043991]
- Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital [14-2016-011]
- National Research Foundation of Korea [2018R1C1B5043991] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study found differences in the lung microbiomes of patients with lung cancer based on PD-L1 expression levels and immunotherapy responses. Neisseria and V. dispar were key bacteria that differed significantly in relation to PD-L1 expression levels and immunotherapy responses.
Background Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, we investigated the differences in the lung microbiomes of patients with lung cancer. Methods 16S rRNA sequencing was performed to evaluate the respiratory tract microbiome present in the bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses. Results In total, 84 patients were prospectively analyzed, of which 59 showed low (< 10%), and 25 showed high (>= 10%) PD-L1 expression levels. The alpha and beta diversities did not significantly differ between the two groups. Veillonella dispar was dominant in the high-PD-L1 group; the population of Neisseria was significantly higher in the low-PD-L1 group than in the high-PD-L1 group. In the immunotherapy responder group, V. dispar was dominant, while Haemophilus influenzae and Neisseria perflava were dominant in the non-responder group. Conclusion The abundances of Neisseria and V. dispar differed significantly in relation to PD-L1 expression levels and immunotherapy responses.
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