期刊
ENVIRONMENTAL RESEARCH
卷 159, 期 -, 页码 239-248出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2017.07.045
关键词
Solar ultraviolet radiation; Vitamin D; Blood; Gene expression; MiRNA expression
资金
- CERCA Programme / Generalitat de Catalunya
- Instituto de Salud Carlos III FEDER [PI10/02235]
- Spanish Ministry of Economy and Competitiveness [MTM2015-68140-R]
- European Commission, under the Framework 7 Programme Environment Theme [227020]
- Strategic Research Area program of the Swedish Research Council through Stockholm University
- UK National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D-3 [250HD(3)] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 250HD(3) levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 250HD(3) and blood cell subpopulations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据