期刊
ANTIBODIES
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/antib10040037
关键词
RNA; engineered mRNA; antibody fragments; multispecific antibodies; next-generation antibodies
类别
资金
- Spanish Ministry of Science and Innovation [SAF2017-89437-P]
- European Regional Development Fund (ERDF)
- Carlos III Health Institute (ISCIII) [PI19/00132]
- ERDF
- Spanish Association Against Cancer [AECC 19084]
- CRIS Cancer Foundation [FCRIS-2018-0042, FCRIS-2021-0090]
Using gene transfer methods for in vivo secretion of therapeutic antibodies can avoid production and purification challenges, achieving sustained concentrations and benefitting short-lived antibody fragments and next-generation, Fc-free, multispecific antibodies.
Monoclonal antibodies are widely used as therapeutic agents in medicine. However, clinical-grade proteins require sophisticated technologies and are extremely expensive to produce, resulting in long lead times and high costs. The use of gene transfer methods for in vivo secretion of therapeutic antibodies could circumvent problems related to large-scale production and purification and offer additional benefits by achieving sustained concentrations of therapeutic antibodies, which is particularly relevant to short-lived antibody fragments and next-generation, Fc-free, multispecific antibodies. In recent years, the use of engineered mRNA-based gene delivery has significantly increased in different therapeutic areas because of the advantages it possesses over traditional gene delivery platforms. The application of synthetic mRNA will allow for the avoidance of manufacturing problems associated with recombinant proteins and could be instrumental in consolidating regulatory approvals for next-generation therapeutic antibodies.
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