期刊
ENVIRONMENTAL POLLUTION
卷 229, 期 -, 页码 412-422出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2017.06.019
关键词
Air pollution; Genomic instability; Particulate matter; Lung cancer
资金
- [SEP-CONACYTCB-2011-180471]
- [SEP-CONACYTCB- 2015-01-255150]
In this review, we summarize and discuss the evidence regarding the interaction between air pollution, especially particulate matter (PM), and genomic instability. PM has been widely studied in the context of several diseases, and its role in lung carcinogenesis gained relevance due to an increase in cancer cases for which smoking does not seem to represent the main risk factor. According to epidemiological and toxicological evidence, PM acts as a carcinogenic factor in humans, inducing high rates of genomic alterations. Here, we discuss not only how PM is capable of inducing genomic instability during the carcinogenic process but also how our genetic background influences the response to the sources of damage. (C) 2017 Elsevier Ltd. All rights reserved.
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