期刊
CURRENT ISSUES IN MOLECULAR BIOLOGY
卷 43, 期 3, 页码 1669-1684出版社
MDPI
DOI: 10.3390/cimb43030118
关键词
estrogen; radix polygalae; cognition; depression; VCD
资金
- BK21 plus program AgeTech-Service Convergence Major through the National Research Foundation (NRF) - Ministry of Education of Korea [5120200313836]
- National Research Foundation of Korea [5120200313836] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Postmenopausal syndrome is characterized by symptoms caused by decreased female hormones after mid-40s, leading to cognitive decline and depressive symptoms. Radix Polygalae, when administered orally in a mouse model of estrogen depletion, showed improvements in memory, reduced depression-related behaviors, and potential neuroprotective effects without increasing serum estradiol levels. These results suggest the possible benefits of Radix Polygalae as a supplement to prevent postmenopausal depression and cognitive decline.
Postmenopausal syndrome refers to symptoms caused by the gradual decrease in female hormones after mid-40 years. As a target organ of estrogen, decrease in estrogen causes various changes in brain function such as a decrease in choline acetyltransferase and brain-derived neurotrophic factor; thus, postmenopausal women experience cognitive decline and more depressive symptoms than age-matched men. Radix Polygalae has been used for memory boosting and as a mood stabilizer and its components have shown neuroprotective, antidepressant, and stress relief properties. In a mouse model of estrogen depletion induced by 4-vinylcyclohexene diepoxide, Radix Polygalae was orally administered for 3 weeks. In these animals, cognitive and depression-related behaviors and molecular changes related to these behaviors were measured in the prefrontal cortex and hippocampus. Radix Polygalae improved working memory and contextual memory and despair-related behaviors in 4-vinylcyclohexene diepoxide-treated mice without increasing serum estradiol levels in this model. In relation to these behaviors, choline acetyltransferase and brain-derived neurotrophic factor in the prefrontal cortex and hippocampus and bcl-2-associated athanogene expression increased in the hippocampus. These results implicate the possible benefit of Radix Polygalae in use as a supplement of estrogen to prevent conditions such as postmenopausal depression and cognitive decline.
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