4.7 Article

Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

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Summary: The new topical gel formulations containing AS1411 aptamer-functionalized polymeric nanocapsules loaded with an antitumoral drug showed promising potential for skin cancer treatment. Characterization tests including rheological, permeation, hemolysis, skin irritation, cytotoxicity and in vivo tests demonstrated the safety and effectiveness of the gel formulations. Nanoencapsulation of 5-Fluorouracil enhanced its permeability and cytotoxicity, making it an attractive option for skin cancer therapy.

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