期刊
GELS
卷 7, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/gels7040215
关键词
dry eye disease; gel-based artificial tears; Herschel-Bulkley model; tear film breakup; VOF method
资金
- Ministry of Higher Education and Scientific Research of Algeria
- Institut Carnot PolyNat [ANR-11-CARN-030-01]
- LabEx Tec 21 [ANR-11-LABX-0030]
This paper discusses the rheological behaviors of gel-based ophthalmic formulation spreading on the cornea surface, investigates the influence of rheological properties on the spreading, and proposes optimal values for efficient gel-based artificial tears.
This paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel-Bulkley model can describe. The continuity and momentum equations are solved numerically using the monofluid formulation and the volume-of-fluid (VOF) method. We investigated the influence of the rheological properties, namely the consistency, the yield stress, and the flow behavior index, on the spreading of a gel-based artificial tear over the cornea surface. We propose optimal values of these properties for efficient gel-based artificial tears.
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