期刊
ENVIRONMENTAL POLLUTION
卷 227, 期 -, 页码 578-586出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2017.04.094
关键词
Brominated flame retardants; OH-TBB; Firemaster (R) 550; BZ-54; PPAR gamma
资金
- Vanier Canada Graduate Scholarship
- Canada Research Chair program, a Visiting Distinguished Professorship in the Department of Biology and Chemistry
- High Level Foreign Experts program - State Administration of Foreign Experts Affairs [GDW20223200120]
- P. R. China to Nanjing University
- Chinese Academy of Sciences
- Natural Science and Engineering Research Council of Canada [326415-07]
- Western Economic Diversification Canada [6578, 6807]
- State Key Laboratory in Marine Pollution, City University of Hong Kong
- Western Economic Diversification (WED) [000012711]
In the current study, by combining ultra-high resolution (UHR) MS1 spectra, MS2 spectra, and derivatization, three hydroxylated isomers of 2-ethylhexyl tetrabromobenzoate (OH-TBB) were identified in Firemaster (R) 550 and BZ-54 technical products. Also, a new LC-UHRMS method, using atmospheric pressure chemical ionization (APCI), was developed for simultaneous analysis of OH-TBB, TBB, hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) and TBPH in 23 samples of dust collected from houses in Saskatoon, SIC, Canada. OH-TBBs were detected in 91% of samples, with a geometric mean concentration of 0.21 ng/g, which was slightly less than those of OH-TBPH (0.35 ng/g). TBB was detected in 100% of samples of dust with a geometric mean concentration of 992 ng/g. Significant (p < 0.001) log linear relationships between concentrations of OH-TBBs, TBB, or OH-TBPHs and TBPH in dust support the hypothesis of a common source of these compounds. OH-TBBs were found to be strong agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) and weaker agonists of the estrogen receptor (ER), but no agonistic potencies was observed with the androgen receptor (AR). Occurrence of OH-TBBs in technical products and house dust, together with their relatively strong PPAR gamma potencies, indicated their potential risk to health of humans. (C) 2017 Elsevier Ltd. All rights reserved.
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