期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 76, 期 11, 页码 2815-2824出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkab269
关键词
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资金
- University of Manitoba
- Shared Health Manitoba
- PHAC-NM L
- Astellas
- Avir/Basilea
- Iterum
- Merck
- Paladin Labs
- Paratek
- Pfizer
- Sunovion
- Tetraphase
- Verity
The proportion of ESBL-producing Escherichia coli and Klebsiella pneumoniae in Canada increased significantly from 2007 to 2018. The most common sequence types were ST131 for E. coli and ST11 and ST147 for K. pneumoniae. Over 97% of the isolates were multidrug-resistant.
Objectives: ESBL-producing Escherichia coli and Klebsiella pneumoniae are pathogens of increasing importance in Canada and elsewhere in the world. The purpose of this study was to phenotypically and molecularly characterize ESBL-producing E. coli and K. pneumoniae clinical isolates obtained from patients attending Canadian hospitals over a 12year period. Methods: Isolates were collected between January 2007 and December 2018 as part of an ongoing national surveillance study (CANWARD). ESBL production was confirmed using the CLSI (M100) phenotypic method. Susceptibility testing was carried out using custom broth microdilution panels, and all isolates underwent WGS. Results: In total, 671 E. coli and 141 K. pneumoniae were confirmed to be ESBL producers. The annual proportion of ESBL-producing isolates increased for both E. coli (from 3.3% in 2007 to 11.2% in 2018; P<0.0001) and K. pneumoniae (from 1.3% in 2007 to 9.3% in 2018; P<0.0001). The most frequent STs were ST131 for E. coli [62.4% (419/671) of isolates] and ST11 [7.8% (11/141)] and ST147 [7.8% (11/141)] for K. pneumoniae. Overall, 97.2% of ESBL-producing E. coli and K. pneumoniae isolates were MDR. bla(CTX-M-15) predominated in both ESBL-producing E. coli (62.3% of isolates) and ESBL-producing K. pneumoniae (48.9% of isolates). Conclusions: The proportion of ESBL-producing E. coli, especially ST131, and K. pneumoniae, especially ST11 and ST147, in Canada increased significantly from 2007 to 2018. Continued prospective surveillance of these evolving MDR and at times XDR pathogens is imperative.
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