4.6 Article

Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis

期刊

AGING-US
卷 13, 期 3, 页码 3588-3604

出版社

IMPACT JOURNALS LLC

关键词

circular RNAs; circFASTKD1; vascular endothelial cells; angiogenesis; myocardial infarction

资金

  1. Key Fund of the Tianjin Health Commission [2014KR01]
  2. Youth Fund of the Tianjin Science and Technology Commission [17JCQNJC10000]
  3. Key Projects for Science and Technology Support in Tianjin [18YFZCSY01080]
  4. Major Science and Technology Projects for Prevention and Treatment of Chronic Diseases in Tianjin [16ZXMJSY00200]
  5. General Project of Tianjin Natural Science Foundation [19JCYBJC26000]
  6. High-level Innovative Talent Program for Young Scholars [YDYYRCXM-C2018-03]

向作者/读者索取更多资源

In this study, it was found that circFASTKD1 inhibits angiogenesis in vascular endothelial cells and silencing of circFASTKD1 has therapeutic effects in hypoxia by promoting angiogenesis.
Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR106a and relieved its inhibition of Large Tumor Suppressor Kinases 1 and 2, thereby suppressing the Yes-Associated Protein signaling pathway. Under both normal and hypoxic conditions, the ectopic expression of circFASTKD1 reduced the viability, migration, mobility and tube formation of vascular endothelial cells, whereas the downregulation of circFASTKD1 induced angiogenesis by promoting these processes. Moreover, downregulation of circFASTKD1 in mice improved cardiac function and repair after myocardial infarction. These findings indicate that circFASTKD1 is a potent inhibitor of angiogenesis after myocardial infarction and that silencing circFASTKD1 exerts therapeutic effects during hypoxia by stimulating angiogenesis in vitro and in vivo.

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