期刊
AGING AND DISEASE
卷 12, 期 8, 页码 1948-1963出版社
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2021.0603
关键词
spermidine; aging; age-related diseases; longevity; autophagy
资金
- National Natural Science Foundation of China [82071593, 81770833]
- Fundamental Research Funds for the Central Universities of Central South University [2019zzts354]
Spermidine, a natural polyamine, has shown promising effects in modulating aging, suppressing age-related diseases, and prolonging lifespan. However, the specific mechanisms of how spermidine exerts its anti-aging effects are yet to be fully understood, but it holds great potential in the diagnosis and treatment of aging and age-related diseases.
High incidences of morbidity and mortality associated with age-related diseases among the elderly population are a socio-economic challenge. Aging is an irreversible and inevitable process that is a risk factor for pathological progression of diverse age-related diseases. Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan. However, the precise mechanisms through which spermidine exerts its anti-aging effects have not been established. In this review, we elucidate on the mechanisms and roles underlying the beneficial effects of spermidine in aging from a molecular and cellular perspective. Moreover, we provide new insights into the promising potential diagnostic and therapeutic applications of spermidine in aging and age-related diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据