4.6 Review

Mitotic inactivation of the cGAS-MITA/STING pathways

期刊

JOURNAL OF MOLECULAR CELL BIOLOGY
卷 13, 期 10, 页码 721-727

出版社

OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjab061

关键词

cGAS; MITA; STING; mitosis; innate immune response; DNA

资金

  1. National Key R&D Program of China [2017YFA0505800]
  2. National Natural Science Foundation of China [31830024, 31630045]
  3. Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2019-I2M-5-071]

向作者/读者索取更多资源

This review summarizes the recent advances in understanding how cGAS responds to chromosomes upon nuclear envelope breakdown and the mechanisms involved in the inactivation of the cGAS-MITA/STING pathways during mitosis in vertebrate cells.
The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-mediator of interferon response factor 3 activation/stimulator of interferon genes (MITA/STING) axis has emerged as a major pathway, which senses microbial or mislocated cellular DNA in the cytosol to trigger innate immune responses. cGAS senses cytosolic DNA without a preference of self- or nonself-DNA. How the cGAS-MITA/STING axis is inactivated upon nuclear envelope breakdown (NEBD) at mitotic entry in vertebrate cells to avoid self-DNA sensing remains unclear until very recently. In this review, we summarize the recent advances on how cGAS responds to chromosomes upon NEBD and the mechanisms involved in the inactivation of the cGAS-MITA/STING pathways in mitosis.

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